I'm new to wizard101 and I have been trying to work out what schools work best together :-D and which ones dont work together
You just have to try them out and see for yourself, it's kinda hard to explain which combos of schools work the best. Depends on your play style mostly.
See what your Primary has shields for, and maybe try them togeather, Like Death, and Life Storm, and Myth Fire, and Ice
Sometimes these combo's work the best yet sometimes they do not. I did a Ice, and Storm wizard once. Ice for the Hit points, and Storm for the high damage attacks. But it mostly depends on how you want to play the game.
So really their is no best and worst, got to see for yourself on which works best for your play style.