Wine With my Nvidia video card I had to set my Wine configuration Graphics>Vertex Shader support: (None) and (uncheck) Allow Pixel Shader
This is a little like fishing in the dark, but doable. To see my mouse pointer I waited for the game to start then I went to options>click on the red gear>Hardware Cursor( OFF)
I Wizards101 running on both Intel(32) and my AMD(64)x2. Game works flawlessly!