I play W101 on a Compaq 110c netbook. It plays well with an occational "jump" in the graphics animation, but is quite tolerable.
One down side is that the resolution on the netbook is a 1024x576 display. This game currently requires a minimum 600 vertical pixel display. This is a real bummer, as I must plug in an external display in order to play the game. I travel a good bit, and this really limits my ability to play the game.
I really wish, that the game could be played on the native netbook display. Then I could play any time, and feel like I'm getting my monies worth out of the whole situation.
A light weight version of the game designed for netbooks would be ideal. Considering that the demographic that this game seems to be aiming toward, tend to have lower end PCs or netbooks, I think it would make sense.